Risk factors of Parkinson's disease in Indian patients
Identifieur interne : 001957 ( Main/Exploration ); précédent : 001956; suivant : 001958Risk factors of Parkinson's disease in Indian patients
Auteurs : M. Behari [Inde] ; Achal K. Srivastava [Inde] ; Radhika R. Das [Inde] ; R. M Pandey [Inde]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 2001.
Abstract
Epidemiological data on risk factors of Parkinson's disease (PD) are not available from India. In a case control study, we investigated environmental and genetic risk factors in the etiology of idiopathic Parkinson's disease. Three hundred seventy-seven patients of Parkinson disease (301 men, 76 women, mean±SD age 56.78±11.08 years) and equal number of age matched (±3 years) neurological controls (271 men, 106 women, mean±SD age 56.62±11.17 years) were included in the study. Conditional logistic regression model was used to determine the risk factors of PD. We found that male gender, family history of Parkinson's disease, past history of depression of up to 10-year duration and well water drinking of more than 10-year duration were significantly associated with occurrence of Parkinson's disease, whereas tobacco smoking of up to 20-year duration and exposure to pets had protective effect. However, tobacco smoking of more than 20-year duration, well water drinking of up to 10-year duration, vegetarian dietary habit, occupation involving physical exertion, rural living, farming, exposure to insecticides, herbicides, rodenticides, alcohol intake and family history of neurodegenerative diseases had no significant correlation with occurrence of PD in the patient population studied. Results of our study support the hypothesis of multifactorial etiology of PD with environmental factors acting on a genetically susceptible host.
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DOI: 10.1016/S0022-510X(01)00578-0
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M Pandey</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:71A57B4C0FAC7A2E9A7F29C0545C73A566F8C8AA</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S0022-510X(01)00578-0</idno><idno type="url">https://api.istex.fr/document/71A57B4C0FAC7A2E9A7F29C0545C73A566F8C8AA/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001679</idno><idno type="wicri:Area/Main/Curation">001443</idno><idno type="wicri:Area/Main/Exploration">001957</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Risk factors of Parkinson's disease in Indian patients</title><author><name sortKey="Behari, M" sort="Behari, M" uniqKey="Behari M" first="M" last="Behari">M. Behari</name><affiliation><wicri:noCountry code="no comma">E-mail: madhuribehari@hotmail.com</wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurology, All India Institute of Medical Sciences, New Delhi-110029</wicri:regionArea><wicri:noRegion>New Delhi-110029</wicri:noRegion></affiliation></author><author><name sortKey="Srivastava, Achal K" sort="Srivastava, Achal K" uniqKey="Srivastava A" first="Achal K" last="Srivastava">Achal K. Srivastava</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurology, All India Institute of Medical Sciences, New Delhi-110029</wicri:regionArea><wicri:noRegion>New Delhi-110029</wicri:noRegion></affiliation></author><author><name sortKey="Das, Radhika R" sort="Das, Radhika R" uniqKey="Das R" first="Radhika R" last="Das">Radhika R. 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M Pandey</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biostatistics, All India Institute of Medical Sciences, New Delhi-110029</wicri:regionArea><wicri:noRegion>New Delhi-110029</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">190</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="49">49</biblScope><biblScope unit="page" to="55">55</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">71A57B4C0FAC7A2E9A7F29C0545C73A566F8C8AA</idno><idno type="DOI">10.1016/S0022-510X(01)00578-0</idno><idno type="PII">S0022-510X(01)00578-0</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological data on risk factors of Parkinson's disease (PD) are not available from India. In a case control study, we investigated environmental and genetic risk factors in the etiology of idiopathic Parkinson's disease. Three hundred seventy-seven patients of Parkinson disease (301 men, 76 women, mean±SD age 56.78±11.08 years) and equal number of age matched (±3 years) neurological controls (271 men, 106 women, mean±SD age 56.62±11.17 years) were included in the study. Conditional logistic regression model was used to determine the risk factors of PD. We found that male gender, family history of Parkinson's disease, past history of depression of up to 10-year duration and well water drinking of more than 10-year duration were significantly associated with occurrence of Parkinson's disease, whereas tobacco smoking of up to 20-year duration and exposure to pets had protective effect. However, tobacco smoking of more than 20-year duration, well water drinking of up to 10-year duration, vegetarian dietary habit, occupation involving physical exertion, rural living, farming, exposure to insecticides, herbicides, rodenticides, alcohol intake and family history of neurodegenerative diseases had no significant correlation with occurrence of PD in the patient population studied. Results of our study support the hypothesis of multifactorial etiology of PD with environmental factors acting on a genetically susceptible host.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Behari, M" sort="Behari, M" uniqKey="Behari M" first="M" last="Behari">M. Behari</name></noRegion><name sortKey="Das, Radhika R" sort="Das, Radhika R" uniqKey="Das R" first="Radhika R" last="Das">Radhika R. Das</name><name sortKey="Pandey, R M" sort="Pandey, R M" uniqKey="Pandey R" first="R. M" last="Pandey">R. M Pandey</name><name sortKey="Srivastava, Achal K" sort="Srivastava, Achal K" uniqKey="Srivastava A" first="Achal K" last="Srivastava">Achal K. Srivastava</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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